Tag: Oxidative Stress
Mitochondrial Health and Antibiotics
Antibiotics are lifesaving medications, but their impact on mitochondrial health is a growing area of concern. Since mitochondria evolved from ancient bacteria (endosymbiotic theory), some antibiotics unintentionally target mitochondrial function, leading to energy deficits, oxidative stress, and long-term metabolic consequences. How Antibiotics Affect Mitochondria 1. Mitochondrial Protein Synthesis Inhibition 2. Increased Oxidative Stress 3. Mitochondrial…
N-Acetylcysteine (NAC) for Oxidative Stress
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress N-acetylcysteine (NAC), a synthetic derivative of the endogenous amino acid L-cysteine and a precursor of GSH, has been used for several decades as a mucolytic and as an antidote to acetaminophen (paracetamol) poisoning. As a mucolytic, NAC breaks the disulfide bonds of…
Why I’m taking Gly-NAC?
Glutathione (GSH) and its precursors (NAC and glycine) are critical in combating oxidative stress, inflammation, and mitochondrial dysfunction. NAC and glycine supplementation shows promise in improving metabolic, reproductive, cardiovascular, and aging-related health outcomes. Combined supplementation (e.g., GlyNAC) often yields synergistic benefits, particularly in aging and chronic disease contexts. Future research should focus on long-term effects,…