Category: Longevity
Excersize Prevents Cancer and Preserves Muscle – two articles
Exercise suppresses tumor growth independent of high fat food intake and associated immune dysfunction Taken together, our data support epidemiological findings showing that exercise suppresses tumor growth independent of BMI, however, our data suggest that high-fat feeding attenuates exercise-mediated immune recognition of tumors. Exercise-Mediated Lowering of Glutamine Availability Suppresses Tumor Growth and Attenuates Muscle Wasting…
Ketogenic Diet Against Dyslipidemia
Metabolic Effects of Ketogenic Diets: Exploring Whole-Body Metabolism in Connection with Adipose Tissue and Other Metabolic Organs The ketogenic diet (KD) is characterized by minimal carbohydrate, moderate protein, and high fat intake, leading to ketosis. It is recognized for its efficiency in weight loss, metabolic health improvement, and various therapeutic interventions. The KD enhances glucose…
Melatonin, Nitric Oxide and Adenosine for Alzheimer’s
Alzheimer’s disease (AD) is a progressive neurodegenerative disease. The accumulation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for the pathogenesis of the disease. The accumulation of Aβ plaques and tau affect the balance in chemical neurotransmitters in the brain. The regulation of melatonin, known for its effectiveness in enhancing…
Nutritional Supplements in Alzheimer’s Disease
https://pubmed.ncbi.nlm.nih.gov/40077790/ Some studies have reported positive effects from specific regimens, such as curcumin (800 mg/day), omega-3 fatty acids (2 g/day), and resveratrol (600 mg/day). Other supplements, like phosphatidylserine (300 mg/day), multinutrient formulations, probiotics, vitamin E (2000 IU/day), and melatonin (3-10 mg/day), also show benefits, though study variability makes conclusions uncertain.
Carnivore Diet Benefits and Risks
Results: The carnivore diet met several NRV thresholds for nutrients such as riboflavin, niacin, phosphorus, zinc, Vitamin B6, Vitamin B12, selenium, and Vitamin A, and exceeded the sodium threshold. However, it fell short in thiamin, magnesium, calcium, and Vitamin C, and in iron, folate, iodine and potassium in some cases. Fibre intake was significantly below recommended…
Klotho: The Anti-Aging Protein and How to Support It
Klotho is a hormone-like protein that has garnered attention as a key longevity factor. Originally identified in mice, where its absence led to premature aging, klotho is now recognized as a modulator of multiple aging pathways in humans.Neuroprotection and Cognitive Health: Klotho levels are associated with improved cognition and brain plasticity. It enhances synaptic signaling…
Glutathione and Probiotic Synergy: The Case for Lactobacillus fermentum ME-3
Glutathione is the body’s most potent intracellular antioxidant, and maintaining its levels is central to healthy aging, detoxification, and immune defense. While glycine and NAC support glutathione synthesis, the probiotic strain Lactobacillus fermentum ME-3 offers a unique biological advantage: it is capable of synthesizing and recycling glutathione inside the body. Direct Glutathione Boost: ME-3 uniquely…
Short-Chain Fatty Acids and Gut Microbiota: Limited but Valuable Energy Contribution
Although humans cannot digest cellulose like ruminant animals, certain fibers are fermented by gut bacteria into short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate.Modest Energy Contribution: SCFAs provide a small but meaningful amount of energy—up to 5–10% of daily caloric intake in fiber-rich diets.Butyrate for Gut Health: Butyrate fuels colonocytes, supports gut barrier…
Seed Oil May Cause Breast Cancer
Editor’s summaryLinoleic acid is the most abundant polyunsaturated fatty acid in the Western-style diet and has been implicated in promoting inflammation and cancer. Koundouros et al. report a mechanism by which linoleic acid can activate the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase, which coordinates growth and nutrient signals (see the Perspective by Jacinto).…