Editor’s summary
Linoleic acid is the most abundant polyunsaturated fatty acid in the Western-style diet and has been implicated in promoting inflammation and cancer. Koundouros et al. report a mechanism by which linoleic acid can activate the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase, which coordinates growth and nutrient signals (see the Perspective by Jacinto). Particularly in certain breast cancer cells that overexpressed fatty acid binding protein 5, mTORC1 was activated by linoleic acid, and this action appeared to be mediated by direct binding of this protein to the regulatory-associated protein of mTOR. —L. Bryan Ray

https://www.science.org/doi/10.1126/science.adm9805