Type 2 Diabetes and Skeletal Muscle Atrophy Vicious Cycle
Recent studies have highlighted a significant interplay between Type 2 Diabetes Mellitus (T2DM) and skeletal muscle atrophy (SMA), commonly known as sarcopenia. This relationship forms a vicious cycle where each condition exacerbates the other, leading to deteriorated muscle health and impaired glucose metabolism. Understanding this connection is crucial for developing effective management strategies. Key Findings:…
Vaccination used to be non-controversial. Why is the COVID vaccines have encountered so much resistance?
The COVID-19 vaccines sparked more resistance than previous vaccines for several reasons, combining scientific, political, social, and psychological factors. Here’s a breakdown: COVID vaccine hesitancy wasn’t about a single issue—it was a perfect storm of rapid development, shifting guidance, political mandates, distrust in institutions, and social media-fueled skepticism. Vaccine Hesitancy in History & Lessons for…
Is vaccination a type of hormesis?
Yes, vaccination can be considered a form of hormesis in a biological sense. Hormesis is the concept that exposure to a low dose of a stressor or toxin can stimulate beneficial adaptive responses, making the organism more resilient to larger doses of the same stressor. How Vaccination Fits the Hormesis Model: ✅ Controlled Exposure to…
Agmatine for Parkinson’s Disease:
The Neuroprotective Effects of Agmatine on Parkinson’s Disease: Focus on Oxidative Stress, Inflammation and Molecular Mechanisms Agmatine (AGM), a naturally occurring polyamine derived from L-arginine, has shown significant potential for neuroprotection in Parkinson’s Disease (PD) due to its multifaceted biological activities, including antioxidant, anti-inflammatory, and anti-apoptotic effects. … …This review highlights agmatine’s promising therapeutic potential…
N-Acetylcysteine (NAC) for Oxidative Stress
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress N-acetylcysteine (NAC), a synthetic derivative of the endogenous amino acid L-cysteine and a precursor of GSH, has been used for several decades as a mucolytic and as an antidote to acetaminophen (paracetamol) poisoning. As a mucolytic, NAC breaks the disulfide bonds of…
02/27/2025 Started Agmatine + Ashwagandha together with the usual stack.
Current stack: Glycine, NAC, Magnesium/AcOH, Taurine, Creatine, Vitamin D. in cold water. Plus hot cacao in the morning. Added Agmatine and Ashwagandha
How Music Shapes Cognitive Health and Longevity
Imagine walking through your city, the rhythm of your footsteps blending with the natural sounds around you. A soft melody plays in your mind, perhaps a tune you composed or an old song that brings back memories. This isn’t just a fleeting pleasure—music is actively reshaping your brain, protecting it from cognitive decline, and even…
Antidepressants Accelerate Dementia
Antidepressant use and cognitive decline in patients with dementia: a national cohort study ConclusionsIn this cohort study, current antidepressant use was associated with faster cognitive decline; furthermore, higher dispensed doses of SSRIs were associated with higher risk for severe dementia, fractures, and all-cause mortality.
Agmatine Page
Agmatine for Brain and Nervous System Pharmacological profile of agmatine: An in-depth overviewAgmatine, a naturally occurring polyamine derived from arginine via arginine decarboxylase, has been shown to play multifaceted roles in the mammalian body, impacting a wide range of physiological and pathological processes. ….Beyond its neuromodulatory functions, agmatine exhibits protective effects across various cellular and…