Agmatine for Brain and Nervous System

Pharmacological profile of agmatine: An in-depth overview
Agmatine, a naturally occurring polyamine derived from arginine via arginine decarboxylase, has been shown to play multifaceted roles in the mammalian body, impacting a wide range of physiological and pathological processes. ….Beyond its neuromodulatory functions, agmatine exhibits protective effects across various cellular and systemic contexts, including neuroprotection, nephroprotection, cardioprotection, and cytoprotection, suggesting a broad therapeutic potential

Agmatine Sulfate is effective against painful small fiber neuropathy
Neuropathic pain is nerve pain that can happen if your nervous system malfunctions or gets damaged. You can feel pain from any of the various levels of your nervous system, including your peripheral nerves, your spinal cord and your brain. Your central nervous system consists of your spinal cord and brain.
“The results suggest that dietary agmatine sulfate has a significant effect in reducing neuropathic pain intensity associated with painful SFN resistant to treatment with conventional neuropathic pain medications. “

Agmatine modulation of gut-brain axis alleviates dysbiosis-induced depression-like behavior in rats
“Antibiotic administration disrupted tight junction proteins in the ileum, affecting gut architecture. Oral administration of agmatine alone or combined with probiotics significantly reversed antibiotic-induced dysbiosis, restoring gut microbiota and mitigating depression-like behaviors. This intervention also restored neuro-inflammatory markers, increased agmatine and monoamine levels, and preserved gut integrity.”