Glutathione and Probiotic Synergy: The Case for Lactobacillus fermentum ME-3
Glutathione is the body’s most potent intracellular antioxidant, and maintaining its levels is central to healthy aging, detoxification, and immune defense. While glycine and NAC support glutathione synthesis, the probiotic strain Lactobacillus fermentum ME-3 offers a unique biological advantage: it is capable of synthesizing and recycling glutathione inside the body. Direct Glutathione Boost: ME-3 uniquely…
Short-Chain Fatty Acids and Gut Microbiota: Limited but Valuable Energy Contribution
Although humans cannot digest cellulose like ruminant animals, certain fibers are fermented by gut bacteria into short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate.Modest Energy Contribution: SCFAs provide a small but meaningful amount of energy—up to 5–10% of daily caloric intake in fiber-rich diets.Butyrate for Gut Health: Butyrate fuels colonocytes, supports gut barrier…
Seed Oil May Cause Breast Cancer
Editor’s summaryLinoleic acid is the most abundant polyunsaturated fatty acid in the Western-style diet and has been implicated in promoting inflammation and cancer. Koundouros et al. report a mechanism by which linoleic acid can activate the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase, which coordinates growth and nutrient signals (see the Perspective by Jacinto).…
Understanding Mitochondrial Quality Control (MQC)
Understanding Mitochondrial Quality Control (MQC) Mitochondria are essential components within our cells, often termed the “powerhouses,” as they generate the energy required for cellular functions. To ensure they operate effectively, cells employ MQC mechanisms, which include:Mitochondrial Biogenesis: The creation of new mitochondria to meet energy demands.Mitochondrial Dynamics: The balance between fusion (joining of mitochondria) and…
Sugar Causes Gout
Incorrect title: Adherence to Healthy and Unhealthy Plant-Based Diets and the Risk of Gout The title should be: Sugar Causes Gout “In analysis of individual food groups, higher intakes of certain healthy plant foods, such as whole grains (pooled HR per 1 serving/d, 0.93 [95% CI, 0.89-0.97]) and tea and coffee (pooled HR per 1…
Fluoride and Its Potential Dangers to the Brain: A Critical Analysis
Fluoride (F⁻) has long been recognized for its dental benefits, primarily in preventing cavities and strengthening enamel. However, emerging research suggests that chronic fluoride exposure—especially at high levels—may have neurotoxic effects, raising concerns about its impact on brain health, cognitive function, and neurodevelopment.This article explores the scientific evidence on fluoride’s potential neurotoxicity, its mechanisms of…
Taste and Smell in Human Diseases
Dysregulation of chemosensory systems may underlie the much higher mortality rate of COVID-19 Acute Respiratory Distress Syndrome (ARDS) compared to ARDSs of different origins. In chronic non-infectious diseases like hypertension, diabetes, or cancer, the impairment of taste and/or olfaction has been consistently reported. This may signal diffuse chemosensory failure, possibly worsening the prognosis of these…
Smell and taste disorders early signs of dementia
Disorders of smell and taste are reported by approximately one-fifth of people 40 years and older, and one-third of people 80 years and older. These disorders affect quality of life and the ability to identify smoke and toxins. Smell and taste disorders can be early signs of dementia or Parkinson disease and are associated with…
If you like the smell of earth you may need more iron
https://pubmed.ncbi.nlm.nih.gov/38222205/ Background: Iron deficiency is a critical global health issue. One of the intriguing manifestations linked to iron deficiency is the presence of pica. The physiological relationship between the senses of smell and taste suggests that pica may be accompanied by an inclination towards the smell of earth (geosmin). The smell of geosmin is distinct and…
Creatine Supplementation for Brain in Older Adults
Long-term high-dosage creatine supplementation increases brain creatine stores. Creatine supplementation can improve cognition and memory, especially in older adults or during times of metabolic stress (i.e., sleep deprivation). Creatine supplementation improves aspects of recovery from traumatic brain injury in children and has the potential to reduce symptoms of depression and anxiety. There is some evidence…