Long-term high-dosage creatine supplementation increases brain creatine stores.

Creatine supplementation can improve cognition and memory, especially in older adults or during times of metabolic stress (i.e., sleep deprivation).

Creatine supplementation improves aspects of recovery from traumatic brain injury in children and has the potential to reduce symptoms of depression and anxiety.

There is some evidence that creatine supplementation improves outcome measures in those with muscular dystrophy but not other neurological diseases or conditions such as Parkinson’s disease or amyotrophic lateral sclerosis.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10721691/