Category: Longevity
Understanding Mitochondrial Quality Control (MQC)
Understanding Mitochondrial Quality Control (MQC) Mitochondria are essential components within our cells, often termed the “powerhouses,” as they generate the energy required for cellular functions. To ensure they operate effectively, cells employ MQC mechanisms, which include:Mitochondrial Biogenesis: The creation of new mitochondria to meet energy demands.Mitochondrial Dynamics: The balance between fusion (joining of mitochondria) and…
Sugar Causes Gout
Incorrect title: Adherence to Healthy and Unhealthy Plant-Based Diets and the Risk of Gout The title should be: Sugar Causes Gout “In analysis of individual food groups, higher intakes of certain healthy plant foods, such as whole grains (pooled HR per 1 serving/d, 0.93 [95% CI, 0.89-0.97]) and tea and coffee (pooled HR per 1…
Fluoride and Its Potential Dangers to the Brain: A Critical Analysis
Fluoride (F⁻) has long been recognized for its dental benefits, primarily in preventing cavities and strengthening enamel. However, emerging research suggests that chronic fluoride exposure—especially at high levels—may have neurotoxic effects, raising concerns about its impact on brain health, cognitive function, and neurodevelopment.This article explores the scientific evidence on fluoride’s potential neurotoxicity, its mechanisms of…
Taste and Smell in Human Diseases
Dysregulation of chemosensory systems may underlie the much higher mortality rate of COVID-19 Acute Respiratory Distress Syndrome (ARDS) compared to ARDSs of different origins. In chronic non-infectious diseases like hypertension, diabetes, or cancer, the impairment of taste and/or olfaction has been consistently reported. This may signal diffuse chemosensory failure, possibly worsening the prognosis of these…
Smell and taste disorders early signs of dementia
Disorders of smell and taste are reported by approximately one-fifth of people 40 years and older, and one-third of people 80 years and older. These disorders affect quality of life and the ability to identify smoke and toxins. Smell and taste disorders can be early signs of dementia or Parkinson disease and are associated with…
If you like the smell of earth you may need more iron
https://pubmed.ncbi.nlm.nih.gov/38222205/ Background: Iron deficiency is a critical global health issue. One of the intriguing manifestations linked to iron deficiency is the presence of pica. The physiological relationship between the senses of smell and taste suggests that pica may be accompanied by an inclination towards the smell of earth (geosmin). The smell of geosmin is distinct and…
Creatine Supplementation for Brain in Older Adults
Long-term high-dosage creatine supplementation increases brain creatine stores. Creatine supplementation can improve cognition and memory, especially in older adults or during times of metabolic stress (i.e., sleep deprivation). Creatine supplementation improves aspects of recovery from traumatic brain injury in children and has the potential to reduce symptoms of depression and anxiety. There is some evidence…
My Approach to Longevity
As a long time reader and follower of the science based approach to health and longevity, here I describe the basis of my current regiment. It may not suit everybody, but works for me. Optimizing Longevity and Health: The Synergistic Benefits of Glycine, NAC, Taurine, Creatine, Vitamins C & D, Niacin, and Magnesium with a…
Leucine and Isoleucine: Longevity and Cancer Risk
Leucine and isoleucine are two essential branched-chain amino acids (BCAAs) that play crucial roles in metabolism, muscle maintenance, and overall health. However, their impact on longevity and cancer risk is complex and depends on dietary intake, metabolic status, and individual health conditions. Leucine: A Double-Edged Sword Longevity BenefitsMuscle Maintenance & Anti-Sarcopenia: Leucine is well-known for…
Optimal dietary patterns for healthy aging
https://pubmed.ncbi.nlm.nih.gov/40128348/ Here, using longitudinal questionnaire data from the Nurses’ Health Study (1986-2016) and the Health Professionals Follow-Up Study (1986-2016), we examined the association of long-term adherence to eight dietary patterns and ultraprocessed food consumption with healthy aging, as assessed according to measures of cognitive, physical and mental health, as well as living to 70 years…