The review by Bleizgys (2024) highlights the synergistic roles of magnesium (Mg), zinc (Zn), and vitamin K in optimizing vitamin D metabolism and clinical outcomes. The following studies provide additional evidence supporting the importance of these nutrients, especially in managing mental health, bone health, and aging-related disorders.

Magnesium and Vitamin D for Mental Health: ADHD Study

A randomized controlled trial published in BMC Pediatrics (2021) investigated the effect of vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) supplementation on the mental health status of children with attention-deficit/hyperactivity disorder (ADHD) over an 8-week period.
Findings and Conclusion: The co-supplementation significantly improved behavioral function and mental health outcomes in children with ADHD.
This supports the hypothesis that magnesium and vitamin D work together to enhance neurological function and reduce symptoms of behavioral disorders, potentially through the regulation of neurotransmitter activity and inflammation.

Bone Health and Aging: Anabolic Effects of Vitamin D and Magnesium

The 2019 review by Erem, Atfi, and Razzaque in the Journal of Steroid Biochemistry and Molecular Biology emphasizes the anabolic effects of vitamin D and magnesium on aging bone.
Key Points:

• Magnesium plays a crucial role in bone health by facilitating calcium metabolism and supporting vitamin D activation.
• Vitamin D enhances the absorption of calcium and phosphorus, which are essential for bone mineralization, while magnesium is required for proper vitamin D metabolism.
• Clinical Implication: Combined supplementation may reduce the risk of osteoporosis and improve bone strength in older adults.

These findings align with Bleizgys’ review, which underscores the importance of assessing and correcting deficiencies in these nutrients to prevent age-related bone loss and ensure calcium homeostasis.

Clinical Implications

Given the evidence from these studies, it is clear that magnesium, zinc, and vitamin K play critical roles in the success of vitamin D supplementation in various health domains:

1. Mental Health – Co-supplementation of vitamin D and magnesium improves behavioral and cognitive function in children with ADHD.
2. Bone Health and Aging – Vitamin D and magnesium promote bone anabolism, enhancing bone density and reducing the risk of fractures in older populations.
3. Immune Function and Inflammation – Zinc and vitamin K contribute to modulating immune responses and reducing inflammation, which is crucial in chronic conditions.

Conclusion

To achieve optimal clinical outcomes, healthcare practitioners should adopt a comprehensive nutritional approach that includes assessing and correcting magnesium, zinc, and vitamin K levels in patients undergoing vitamin D supplementation. This approach is particularly relevant in conditions involving mental health, aging, and bone health, where deficiencies in these nutrients may limit the therapeutic potential of vitamin D.